https://www.ttsclinical.com/blogs/news/lipid-soluble-vitamin-c-stability 2026-10-07T05:03:53-06:00 weekly https://www.ttsclinical.com/blogs/news/why-topical-vitamin-c-needs-ph-below-3-5 2026-10-07T05:03:53-06:00 weekly https://www.ttsclinical.com/blogs/news/medical-grade-skincare-mechanism-glossary 2026-10-07T05:03:53-06:00 weekly https://www.ttsclinical.com/blogs/news/molecular-weight-skin-penetration-500-dalton-rule 2026-10-07T05:03:53-06:00 weekly https://www.ttsclinical.com/blogs/news/why-retinol-must-convert-to-retinoic-acid 2026-10-07T05:03:53-06:00 weekly https://www.ttsclinical.com/blogs/news/do-topical-peptides-increase-collagen-trial-evidence 2026-10-07T05:03:53-06:00 weekly https://cdn.shopify.com/s/files/1/1076/2970/7589/articles/tts-peptides-trial-evidence.png?v=1788937670 Do Topical Peptides Increase Collagen? What Controlled Trials Show Figure: of 19 randomised controlled trials pooled in a 2026 meta-analysis of peptides for skin ageing, 17 tested oral formulations and only 2 tested topical application. Unit chart with 19 squares, two highlighted. https://www.ttsclinical.com/blogs/news/stratum-corneum-lipid-ratio-ceramides 2026-10-07T05:03:53-06:00 weekly https://cdn.shopify.com/s/files/1/1076/2970/7589/articles/tts-lipidos-estrato-corneo.png?v=1788937678 Why Isn't a Ceramide Cream Enough? The Lipid Ratio of the Stratum Corneum Figura: comparación de la distancia de repetición de la fase laminar de periodicidad larga en modelos de estrato córneo. Con ácido graso saturado, 125,7 Å; con ácido oleico insaturado, 139,6 Å, una membrana más fluida y permeable. https://www.ttsclinical.com/blogs/news/do-vitamin-e-and-ferulic-acid-stabilise-topical-vitamin-c 2026-10-07T05:03:53-06:00 weekly https://cdn.shopify.com/s/files/1/1076/2970/7589/articles/thdc-singlet-oxygen-degradation-2026.png?v=1789476362 Do Vitamin E and Ferulic Acid Actually Stabilise Topical Vitamin C? Bar chart: tetrahexyldecyl ascorbate alone is fully degraded at 6 minutes under singlet oxygen, and 25% degraded at 10 minutes when combined with a stabilising antioxidant. Source: Swindell et al., Int J Mol Sci 2021;22:8756. https://www.ttsclinical.com/blogs/news/does-niacinamide-increase-skin-barrier-lipids 2026-10-07T05:03:53-06:00 weekly https://cdn.shopify.com/s/files/1/1076/2970/7589/articles/nicotinamide-lipid-synthesis-2026.png?v=1789476421 Does Niacinamide Increase the Skin's Own Barrier Lipids? Bar chart: nicotinamide raises lipid synthesis in cultured human keratinocytes. Glucosylceramide 7.4x, ceramides 4.1-5.5x, sphingomyelin 3.1x, free fatty acids 2.3x, cholesterol 1.5x. Source: Tanno et al., Br J Dermatol 2000;143:524. https://www.ttsclinical.com/blogs/news/stable-vitamin-c-ester-is-not-a-stable-serum 2026-10-07T05:04:23-06:00 weekly https://www.ttsclinical.com/blogs/news/what-changes-in-skin-after-50 2026-10-07T05:04:23-06:00 weekly https://cdn.shopify.com/s/files/1/1076/2970/7589/articles/tts-blog-post-1.png?v=1789827736 What Actually Changes in Your Skin After 50 (and What It Actually Needs) Abstract illustration: a row of outlined circles increasing in size from left to right on an ivory background. https://www.ttsclinical.com/blogs/news/why-patients-dont-improve-between-visits 2026-10-07T05:04:23-06:00 weekly https://cdn.shopify.com/s/files/1/1076/2970/7589/articles/tts-blog-post-2.png?v=1789827783 Why Patients Don't Improve Between Visits — and What Home Care Has to Do With It Abstract illustration: outlined circles ascending in a diagonal sequence towards two larger filled circles, on an ivory background. https://www.ttsclinical.com/blogs/news/same-serum-different-results-delivery 2026-10-07T05:04:24-06:00 weekly https://cdn.shopify.com/s/files/1/1076/2970/7589/articles/tts-blog-post-3.png?v=1789827811 Same Serum, Different Results: Why Delivery Determines Whether an Active Performs Abstract illustration: concentric outlined rings around a small filled centre, suggesting layers, on an ivory background. https://www.ttsclinical.com/blogs/news/fed-not-covered-what-skin-is-built-from 2026-10-07T05:04:24-06:00 weekly https://cdn.shopify.com/s/files/1/1076/2970/7589/articles/tts-blog-post-4.png?v=1789827843 Fed, Not Covered: Why Your Skin Needs What It's Actually Built From Abstract illustration: two overlapping outlined circles above two smaller circles, on an ivory background. https://www.ttsclinical.com/blogs/news/how-skin-penetration-is-measured-franz-cells 2026-10-07T05:04:24-06:00 weekly https://cdn.shopify.com/s/files/1/1076/2970/7589/articles/tts-franz-cell-permeation-2026-09-22.png?v=1790104822 How Is Skin Penetration Actually Measured? Franz Cells, Split-Thickness Skin and What the Numbers Mean Figure: cumulative permeation of 3-O-ethyl-L-ascorbic acid at 24 hours in Franz cells, human epidermis 49.4 micrograms per square centimetre versus reconstructed skin equivalent 41.3. https://www.ttsclinical.com/blogs/news/why-skin-surface-ph-matters-acid-mantle 2026-10-07T05:04:24-06:00 weekly https://cdn.shopify.com/s/files/1/1076/2970/7589/articles/tts-skin-surface-ph-acidification-en-2026-09-22.png?v=1790104875 Why Does the Skin's Own pH Matter? The Acid Mantle and the Enzymes of the Barrier Figure: contributions to skin surface acidity in pH units. Extracellular lipid processing about 1.00, filaggrin catabolism about 0.50, NHE1 antiporter about 0.25. https://www.ttsclinical.com/blogs/news/does-a-penetration-enhancer-have-to-damage-the-barrier 2026-10-07T05:04:24-06:00 weekly https://cdn.shopify.com/s/files/1/1076/2970/7589/articles/penetration-enhancer-barrier-cost.png?v=1790770920 Does a Penetration Enhancer Have to Damage the Skin Barrier to Work? Bar chart: cumulative diclofenac recovered over 24 h in ex vivo human skin. Vehicle alone 8.2 micrograms per square centimetre, oleyl alcohol 0.75 percent 23, oleic acid 0.75 percent 21. Source: Kovacik et al., Molecular Pharmaceutics 2023. https://www.ttsclinical.com/blogs/news/why-glycolic-acid-percentage-depends-on-ph 2026-10-07T05:04:24-06:00 weekly https://cdn.shopify.com/s/files/1/1076/2970/7589/articles/glycolic-acid-free-acid-ph.png?v=1790770928 Why Does the Same Percentage of Glycolic Acid Behave Differently at Different pH? Figure: glycolic acid, pKa about 3.83. At pH 3.8 half is free acid, giving about 4 percent free acid from an 8 percent formulation; at pH 4.5 only 18 percent, giving about 1.4 percent. Source: Cambier et al., Cosmetics 2026. https://www.ttsclinical.com/blogs/news/do-hair-follicles-deliver-more-active-than-skin-surface 2026-10-12T23:33:55-06:00 weekly https://cdn.shopify.com/s/files/1/1076/2970/7589/articles/tts-follicular-route-reduction-2026-10-13.png?v=1791869635 Do Hair Follicles Deliver More of an Active Than the Skin Surface Does? Bar chart: plugging 30 of 60 hair follicles in excised pig ear skin cuts permeability by about 50% for hydrophilic and ionised compounds and under 20% for non-ionised lipophiles (Mohd et al., Pharmaceutics 2016). https://www.ttsclinical.com/blogs/news/what-does-transepidermal-water-loss-actually-measure 2026-10-12T23:34:06-06:00 weekly https://cdn.shopify.com/s/files/1/1076/2970/7589/articles/tts-tewl-site-spread-2026-10-13.png?v=1791869646 What Does Transepidermal Water Loss Actually Measure? Bar chart of transepidermal water loss: 2.3 g/m2/h pooled on breast skin, 11.60-12.34 in healthy controls, 18.45 on psoriasis plaques, 28.68 on eczema, 44.0 pooled in the axilla (Akdeniz 2018; Montero-Vilchez 2021). https://www.ttsclinical.com/blogs/news/do-topical-peptides-reach-the-living-layers-of-skin 2026-10-21T10:31:50-06:00 weekly https://cdn.shopify.com/s/files/1/1076/2970/7589/articles/peptide-skin-levels-kttks.png?v=1792600310 Do Topical Peptides Reach the Living Layers of Skin? What Measured Skin Levels Show Bar chart of measured palmitoyl-KTTKS in mouse skin: 4.2 µg/cm² in the stratum corneum, 2.8 in the epidermis, 0.3 in the dermis, while unmodified KTTKS was not detected in any layer. Source: Choi et al., Biomolecules & Therapeutics, 2014. https://www.ttsclinical.com/blogs/news/is-there-a-ceiling-on-vitamin-c-uptake-by-skin-cells 2026-10-21T10:31:59-06:00 weekly https://cdn.shopify.com/s/files/1/1076/2970/7589/articles/svct-km-vitamin-c-transport.png?v=1792600319 Is There a Ceiling on How Much Vitamin C a Skin Cell Can Take Up? Range chart of reported Michaelis constants for the sodium-dependent vitamin C transporters: SVCT2 at 8–69 µM and SVCT1 at 65–252 µM, with the plasma steady-state plateau of 70–80 µM for comparison. Source: Lykkesfeldt & Tveden-Nyborg, Nutrients, 2019.